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Trade Name	Drug Name	Approved	Patent Expires	Indication
Corgard	Nadolol	1982-01-01		Heart failure , Hypertension , Myocardial infarction , Angina pectoris , Nephrotic syndrome , Edema
Lucemyra	Lofexidine	2018-05-16		Substance withdrawal syndrome
Melphalan	Melphalan	2019-05-03	2029-2036	Myeloid leukemia acute , Breast neoplasms , Ovarian neoplasms , Non-hodgkin lymphoma , Multiple myeloma , Neuroblastoma , Precursor cell lymphoblastic leukemia-lymphoma , Hematopoietic stem cell transplantation , Hodgkin disease , Rhabdomyosarcoma
Revonto	Dantrolene	2007-07-24	2025	Multiple sclerosis, Spinal cord injuries, Cerebral infarction, Muscle spasticity, Cerebral palsy, Malignant hyperthermia, Neuroleptic malignant syndrome

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

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Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

AFAMITRESGENE AUTOLEUCEL

ovarian neoplasms

,

non-small-cell lung carcinoma

,

stomach neoplasms

,

head and neck neoplasms

,

esophageal neoplasms

,

urinary bladder neoplasms

,

,

,

synovial sarcoma

,

myxoid liposarcoma

,

,

,

,

neurofibrosarcoma

b-cell lymphoma

,

inflammatory breast neoplasms

,

immunoglobulin light-chain amyloidosis

,

myeloproliferative disorders

,

primary myelofibrosis

,

promyelocytic leukemia acute

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

systemic scleroderma

,

diffuse scleroderma

,

,

large b-cell lymphoma diffuse

,

,

myeloid leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

non-hodgkin lymphoma

,

lymphoid leukemia

,

,

myeloid leukemia

,

myelodysplastic syndromes

,

multiple myeloma

,

plasma cell neoplasms

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

b-cell chronic lymphocytic leukemia

,

triple negative breast neoplasms

,

refractory anemia with excess of blasts

,

renal insufficiency

,

hematologic diseases

,

blood protein disorders

,

neoplasms by histologic type

,

paraproteinemias

,

hodgkin disease

,

diabetes mellitus

,

type 1 diabetes mellitus

,

prolymphocytic leukemia t-cell

,

prolymphocytic leukemia

,

,

burkitt lymphoma

,

graft vs host disease

,

bronchiolitis obliterans syndrome

,

aplastic anemia

,

breast neoplasms

,

brain stem neoplasms

,

glycogen storage disease type ii

,

glycogen storage disease type iii

,

ovarian neoplasms

,

hematologic neoplasms

healthy volunteers/patients

,

,

central nervous system neoplasms

,

nephrotic syndrome

,

laryngeal diseases

,

chronic hepatitis

,

,

esophageal neoplasms

,

postmenopausal osteoporosis

,

,

irritable bowel syndrome

,

pathologic dilatation

,

germ cell and embryonal neoplasms

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

oligodendroglioma

,

primitive neuroectodermal tumors

,

,

,

neuroepithelial neoplasms

,

hypertrophic pyloric stenosis

,

ganglioneuroblastoma

,

phenylketonurias

,

neuroendocrine tumors

,

b-cell lymphoma marginal zone

,

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

rectal diseases

,

gastrointestinal diseases

,

intestinal neoplasms

,

digestive system diseases

,

colonic diseases

,

intestinal diseases

,

autism spectrum disorder

,

drug hypersensitivity

,

renal cell carcinoma

,

,

,

squamous cell carcinoma of head and neck

,

head and neck neoplasms

,

b-cell lymphoma

,

squamous cell carcinoma

,

large b-cell lymphoma diffuse

,

pancreatic ductal carcinoma

,

,

,

uveal neoplasms

,

,

mantle-cell lymphoma

,

multiple myeloma

,

myocardial infarction

,

kidney neoplasms

,

hereditary sensory and autonomic neuropathies

,

myelodysplastic syndromes

,

endometrial neoplasms

,

bronchiolitis obliterans syndrome

,

coronary artery disease

,

hypersensitivity

,

philadelphia chromosome

,

lymphoid leukemia

,

,

squamous cell neoplasms

,

waldenstrom macroglobulinemia

,

myeloid leukemia acute

,

castration-resistant prostatic neoplasms

,

hypertrophic cardiomyopathy

,

acute coronary syndrome

,

myocardial ischemia

,

unstable angina

,

margins of excision

,

gouty arthritis

,

gastrointestinal stromal tumors

,

,

,

retinitis pigmentosa

,

,

,

,

,

portal hypertension

,

atopic dermatitis

,

,

,

,

peritoneal neoplasms

,

intestinal obstruction

,

invasive hydatidiform mole

,

central serous chorioretinopathy

,

,

epstein-barr virus infections

,

oropharyngeal neoplasms

,

hodgkin disease

,

type 1 diabetes mellitus

,

,

neurofibrosarcoma

,

ovarian neoplasms

,

fallopian tube neoplasms

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

netherton syndrome

,

,

eosinophilic esophagitis

,

,

systemic mastocytosis

,

mast-cell leukemia

,

,

,

female infertility

,

sickle cell anemia

,

streptococcus agalactiae

,

angioid streaks

,

pseudoxanthoma elasticum

,

granulomatosis with polyangiitis

,

anti-neutrophil cytoplasmic antibody-associated vasculitis

,

microscopic polyangiitis

,

diffuse scleroderma

,

t-cell lymphoma

,

malignant mesothelioma

,

clear cell adenocarcinoma

,

,

adenomyoepithelioma

,

colorectal neoplasms

,

non-small-cell lung carcinoma

,

,

bcr-abl positive chronic myelogenous leukemia

,

,

,

prostatic neoplasms

,

,

myeloid leukemia

,

triple negative breast neoplasms

,

,

follicular lymphoma

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

,

cardiovascular diseases

,

hypercholesterolemia

,

graft vs host disease

,

,

psoriatic arthritis

,

,

rheumatoid arthritis

,

non-hodgkin lymphoma

,

meningococcal meningitis

,

meningococcal infections

,

rectal neoplasms

,

osteitis deformans

,

,

degenerative myopia

,

stomach neoplasms

,

,

neoplasms by site

,

inferior wall myocardial infarction

,

,

psychology rejection

,

organ transplantation

,

graft rejection

,

adenocarcinoma of lung

,

,

aplastic anemia

,

,

carcinoid tumor

,

,

chronic hepatitis c

,

lupus nephritis

,

,

colonic neoplasms

,

retinopathy of prematurity

,

polycythemia vera

,

male breast neoplasms

,

,

,

,

hematologic neoplasms

,

neoplasms by histologic type

,

left ventricular dysfunction

,

st elevation myocardial infarction

,

non-st elevated myocardial infarction

,

,

,

,

infectious skin diseases

,

soft tissue infections

,

,

malignant carcinoid syndrome

,

serotonin syndrome

,

erectile dysfunction

,

peanut hypersensitivity

,

allergic rhinitis seasonal

,

,

,

haemophilus infections

,

,

cerebrotendinous xanthomatosis

,

,

muscular diseases

,

muscular atrophy

,

spinal muscular atrophy

,

x-linked bulbo-spinal atrophy

,

neovascular glaucoma

,

,

thrombocytopenic purpura idiopathic

,

thrombocytopenia

,

chronic obstructive pulmonary disease

,

,

alpha 1-antitrypsin deficiency

,

lymphoproliferative disorders

,

primary myelofibrosis

,

progressive supranuclear palsy

,

pick disease of the brain

,

,

breast neoplasms

,

,

macular degeneration

,

,

,

,

kidney transplantation

,

vision disorders

,

choroidal neovascularization

,

type 2 diabetes mellitus

,

neoplasm metastasis

,

retinal vein occlusion

,

chronic urticaria

,

diabetes mellitus

,

liver transplantation

,

essential hypertension

,

multiple sclerosis

,

diabetic retinopathy

,

brain neoplasms

,

relapsing-remitting multiple sclerosis

,

kidney diseases

,

metabolic syndrome

,

renal insufficiency

,

,

pancreatic neoplasms

,

,

chronic kidney failure

,

,

retinal diseases

,

systolic heart failure

,

insulin resistance

,

,

geographic atrophy

,

parkinson disease

,

diastolic heart failure

,

chronic renal insufficiency

,

,

diabetic nephropathies

,

wet macular degeneration

,

,

,

retinal neovascularization

,

polypoidal choroidal vasculopathy

,

liver cirrhosis

,

,

diabetes complications

,

isolated systolic hypertension

,

systolic murmurs

,

,

left ventricular hypertrophy

,

,

glucose intolerance

,

,

chronic progressive multiple sclerosis

,

,

,

membranous glomerulonephritis

,

,

,

pathologic neovascularization

,

tick-borne encephalitis

,

,

,

,

renal replacement therapy

,

,

prehypertension

,

,

staphylococcal skin infections

,

,

,

neurobehavioral manifestations

,

heart transplantation

,

pituitary acth hypersecretion

,

cystic fibrosis

,

allergic bronchopulmonary aspergillosis

,

,

pituitary neoplasms

,

,

sexual infantilism

,

heart-lung transplantation

,

,

coronavirus infections

,

,

polyomavirus infections

,

retinal detachment

,

atrial fibrillation

,

iga glomerulonephritis

,

focal segmental glomerulosclerosis

,

nephrosclerosis

,

allergic conjunctivitis

,

reperfusion injury

,

delayed graft function

,

food hypersensitivity

,

islet cell adenoma

,

metabolic bone diseases

,

cryopyrin-associated periodic syndromes

,

,

,

,

immunosuppression therapy

,

angina pectoris

,

microvascular angina

,

spinal muscular atrophies of childhood

,

hematopoietic stem cell transplantation

,

secondary prevention

LETETRESGENE AUTOLEUCEL

multiple myeloma

,

plasma cell neoplasms

,

,

non-small-cell lung carcinoma

,

,

,

synovial sarcoma

Globulin, immune

myelodysplastic syndromes

,

graft vs host disease

,

bcr-abl positive chronic myelogenous leukemia

,

myeloid leukemia

,

,

myeloid leukemia acute

,

hematologic neoplasms

,

discoid lupus erythematosus

,

lupus nephritis

,

central nervous system lupus vasculitis

,

,

systemic lupus erythematosus

,

central nervous system vasculitis

,

cutaneous lupus erythematosus

,

,

neoplasm metastasis

,

gastrointestinal neoplasms

,

biliary tract neoplasms

,

colorectal neoplasms

,

,

,

b-cell lymphoma

,

,

pancreatic neoplasms

,

mantle-cell lymphoma

,

,

,

,

urinary bladder neoplasms

,

liver cirrhosis

,

,

chronic hepatitis b

,

,

hepatocellular carcinoma

,

squamous cell carcinoma of head and neck

,

liver neoplasms

,

urologic neoplasms

,

transitional cell carcinoma

,

,

invasive hydatidiform mole

,

brain neoplasms

,

large b-cell lymphoma diffuse

,

b-cell leukemia

,

rectal neoplasms

,

castration-resistant prostatic neoplasms

,

endometrial neoplasms

,

esophageal neoplasms

,

uterine cervical neoplasms

,

ovarian epithelial carcinoma

,

colonic neoplasms

,

multiple myeloma

,

precursor cell lymphoblastic leukemia-lymphoma

,

plasma cell neoplasms

,

,

prolymphocytic leukemia

,

thyroid diseases

,

chronic renal insufficiency

,

kidney diseases

,

chronic hepatitis

,

prostatic neoplasms

,

renal cell carcinoma

,

,

small cell lung carcinoma

,

liver transplantation

,

,

non-alcoholic fatty liver disease

,

,

sclerosing cholangitis

,

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

large-cell lymphoma anaplastic

,

gastrointestinal diseases

,

,

relapsing-remitting multiple sclerosis

,

papillary thyroid cancer

,

medullary carcinoma

,

,

hairy cell leukemia

,

reactive arthritis

,

prolymphocytic leukemia b-cell

,

ovarian neoplasms

,

male breast neoplasms

,

,

thyroid neoplasms

,

anaplastic thyroid carcinoma

,

autoimmune diseases

,

respiratory syncytial virus infections

,

,

mouth neoplasms

,

oropharyngeal neoplasms

,

laryngeal neoplasms

,

hypopharyngeal neoplasms

,

,

b-cell chronic lymphocytic leukemia

,

,

breast neoplasms

,

non-hodgkin lymphoma

,

,

lymphoid leukemia

,

non-small-cell lung carcinoma

,

follicular lymphoma

,

triple negative breast neoplasms

,

waldenstrom macroglobulinemia

,

b-cell lymphoma marginal zone

,

stomach neoplasms

,

rheumatoid arthritis

,

psoriatic arthritis

,

,

,

acquired immunodeficiency syndrome

,

chronic hepatitis c

,

appendiceal neoplasms

,

cystadenocarcinoma

,

neoplasms by histologic type

,

,

chromosome aberrations

,

female genital neoplasms

,

castration-resistant prostatic neoplasms

,

leukemia myeloid chronic atypical bcr-abl negative

,

,

,

cutaneous malignant melanoma

,

deltaretrovirus infections

,

htlv-i infections

,

composite lymphoma

,

pelvic neoplasms

,

abdominal neoplasms

,

urogenital neoplasms

,

gastrointestinal stromal tumors

,

squamous cell carcinoma of head and neck

,

,

invasive hydatidiform mole

,

plasmablastic lymphoma

,

,

adult t-cell leukemia-lymphoma

,

non-small-cell lung carcinoma

,

head and neck neoplasms

,

myeloid leukemia chronic-phase

,

thyroid neoplasms

,

aids-related lymphoma

,

t-cell lymphoma cutaneous

,

intestinal neoplasms

,

primary effusion lymphoma

,

desmoplastic small round cell tumor

,

,

gastrointestinal neoplasms

,

cholangiocarcinoma

,

germ cell and embryonal neoplasms

,

,

adenoid cystic carcinoma

,

thyroid diseases

,

squamous cell carcinoma

,

ductal carcinoma

,

,

urologic neoplasms

,

primitive neuroectodermal tumors

,

primary myelofibrosis

,

uterine cervical neoplasms

,

salivary gland neoplasms

,

breast carcinoma in situ

,

anaplastic thyroid carcinoma

,

thymus neoplasms

,

embryonal rhabdomyosarcoma

,

thrombocytopenia

,

healthy volunteers/patients

,

hypersensitivity

,

hairy cell leukemia

,

lymphomatoid granulomatosis

,

sezary syndrome

,

mycosis fungoides

,

,

,

myeloid leukemia accelerated phase

,

plasma cell leukemia

,

,

carcinoma in situ

,

endocrine gland neoplasms

,

bile duct neoplasms

,

esophageal squamous cell carcinoma

,

graft vs host disease

,

,

alveolar rhabdomyosarcoma

,

neurotoxicity syndromes

,

,

,

neuroendocrine tumors

,

nervous system neoplasms

,

,

intestinal diseases

,

intraocular lymphoma

,

castleman disease

,

,

phenylketonurias

,

b-cell leukemia

,

,

hereditary breast and ovarian cancer syndrome

,

adenomyoepithelioma

,

testicular neoplasms

,

,

neuroepithelial neoplasms

,

islet cell adenoma

,

,

pancreatic ductal carcinoma

,

myxoid liposarcoma

,

,

,

chemotherapy-related cognitive impairment

,

immunoglobulin light-chain amyloidosis

,

,

renal insufficiency

,

,

human herpesvirus 8

,

cortical blindness

,

blastic plasmacytoid dendritic cell neoplasm

,

antineoplastic combined chemotherapy protocols

,

paranasal sinus neoplasms

,

febrile neutropenia

,

neoplasms by site

,

thromboembolism

,

,

hereditary sensory and autonomic neuropathies

,

,

gene rearrangement

,

prolymphocytic leukemia t-cell

,

,

,

cardiovascular abnormalities

,

prosthesis failure

,

,

essential thrombocythemia

,

polycythemia vera

,

diffuse intrinsic pontine glioma

,

hemolytic anemia autoimmune

,

hemolytic anemia

,

,

experimental neoplasms

,

fibrous tissue neoplasms

,

optic nerve glioma

,

oligodendroglioma

,

disease progression

,

,

neurofibromatosis 1

,

neurofibromatoses

,

,

,

,

,

zollinger-ellison syndrome

,

post-traumatic stress disorders

,

,

,

,

adenoviridae infections

,

respiratory aspiration

,

mouth neoplasms

,

,

large cell carcinoma

,

vaginal neoplasms

,

vulvar neoplasms

,

epithelioid hemangioendothelioma

,

vascular neoplasms

,

disorders of sex development

,

adipose tissue neoplasms

,

smooth muscle tumor

,

granular cell tumor

,

endometrial stromal sarcoma

,

minimally invasive surgical procedures

,

cystic fibrosis

,

vascular stiffness

,

triple negative breast neoplasms

,

ovarian neoplasms

,

neoplasm metastasis

,

,

stomach neoplasms

,

,

,

monocytic leukemia acute

,

myelomonocytic leukemia acute

,

erythroblastic leukemia acute

,

,

ovarian epithelial carcinoma

,

megakaryoblastic leukemia acute

,

inflammatory breast neoplasms

,

,

prostatic neoplasms

,

endometrial neoplasms

,

male breast neoplasms

,

kidney neoplasms

,

,

,

bcr-abl positive chronic myelogenous leukemia

,

fallopian tube neoplasms

,

esophageal neoplasms

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

,

congenital abnormalities

,

myeloproliferative disorders

,

transitional cell carcinoma

,

b-cell chronic lymphocytic leukemia

,

myelomonocytic leukemia chronic

,

colorectal neoplasms

,

cardiovascular diseases

,

small cell lung carcinoma

,

,

,

pancreatic neoplasms

,

endometrioid carcinoma

,

hematologic neoplasms

,

,

b-cell lymphoma marginal zone

,

basophilic leukemia acute

,

refractory anemia with excess of blasts

,

,

,

,

eosinophilic leukemia acute

,

malignant fibrous histiocytoma

,

neoadjuvant therapy

,

,

myelodysplastic-myeloproliferative diseases

,

precursor b-cell lymphoblastic leukemia-lymphoma

,

large-cell lymphoma immunoblastic

,

acinar cell carcinoma

,

ureteral neoplasms

,

serous cystadenocarcinoma

,

renal cell carcinoma

,

peritoneal neoplasms

,

,

waldenstrom macroglobulinemia

,

extranodal nk-t-cell lymphoma

,

t-cell leukemia

,

mucinous cystadenocarcinoma

,

ductal carcinoma breast

,

,

synovial sarcoma

,

neurofibrosarcoma

,

malignant mesothelioma

,

mucinous adenocarcinoma

,

hemangiosarcoma

,

brain neoplasms

,

neuroectodermal tumors

,

nerve sheath neoplasms

,

,

refractory anemia

,

urethral neoplasms

,

primitive neuroectodermal tumors peripheral

,

benign fibrous histiocytoma

,

ganglioneuroblastoma

,

myelomonocytic leukemia juvenile

,

acquired immunodeficiency syndrome

,

,

adrenocortical carcinoma

,

drug-related side effects and adverse reactions

,

central nervous system neoplasms

,

eyelid neoplasms

,

residual neoplasm

,

hypereosinophilic syndrome

,

,

dermatofibrosarcoma

,

,

uterine neoplasms

,

clear cell adenocarcinoma

,

left ventricular dysfunction

,

,

lobular carcinoma

,

,

,

clear cell sarcoma

,

epstein-barr virus infections

,

interdigitating dendritic cell sarcoma

,

reactive arthritis

,

solitary fibrous tumors

,

myeloid sarcoma

,

pathologic complete response

,

gallbladder neoplasms

,

induction chemotherapy

,

chemotherapy-induced febrile neutropenia

,

,

connective and soft tissue neoplasms

,

,

colonic neoplasms

,

adjuvant chemotherapy

,

,

hematologic diseases

,

ventricular dysfunction

,

hemangiopericytoma

,

pheochromocytoma

,

lymphadenopathy

,

alveolar soft part sarcoma

,

,

plasma cell granuloma

,

rectal neoplasms

,

adenosquamous carcinoma

,

lymphatic diseases

,

hemophagocytic lymphohistiocytosis

,

pulmonary blastoma

,

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

,

postoperative complications

,

perivascular epithelioid cell neoplasms

,

mesenchymal chondrosarcoma

,

choroid plexus neoplasms

,

retinal neoplasms

,

,

extravasation of diagnostic and therapeutic materials

,

progression-free survival

,

beckwith-wiedemann syndrome

,

adrenal cortex neoplasms

,

unknown primary neoplasms

,

respiratory insufficiency

,

connective tissue neoplasms

,

diastolic heart failure

,

,

positron-emission tomography

,

adolescent development

,

breast neoplasms

,

,

,

myeloid leukemia acute

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

large b-cell lymphoma diffuse

,

non-hodgkin lymphoma

,

,

myeloid leukemia

,

b-cell lymphoma

,

hodgkin disease

,

lymphoid leukemia

,

,

liver neoplasms

,

myelodysplastic syndromes

,

,

hepatocellular carcinoma

,

multiple myeloma

,

burkitt lymphoma

,

follicular lymphoma

,

t-cell lymphoma peripheral

,

t-cell lymphoma

,

plasma cell neoplasms

,

,

urinary bladder neoplasms

,

mantle-cell lymphoma

,

,

,

biphenotypic leukemia acute

,

large-cell lymphoma anaplastic

,

rhabdomyosarcoma

,

cardiomyopathies

,

promyelocytic leukemia acute

,

philadelphia chromosome

,

immunoblastic lymphadenopathy

,

,

enteropathy-associated t-cell lymphoma

,

brain stem neoplasms

,

takotsubo cardiomyopathy

,

lymphoproliferative disorders

,

non-muscle invasive bladder neoplasms

,

breast diseases

,

second primary neoplasms

,

,

,

systolic heart failure

,

mediastinal neoplasms

,

,

male infertility

,

,

circulating neoplastic cells

,

,

alopecia areata

,

peripheral nervous system diseases

,

myocardial infarction

,

,

wounds and injuries

,

carcinoid tumor

,

,

erectile dysfunction

,

diabetic neuropathies

,

,

biliary tract neoplasms

,

,

ataxia telangiectasia

,

,

cerebellar ataxia

,

cardiac rehabilitation

,

chromosome disorders

,

gonadal disorders

,

,

cerebrovascular disorders

,

retroperitoneal neoplasms

,

endomyocardial fibrosis

,

pseudomyxoma peritonei

,

therapeutic chemoembolization

,

liver transplantation

,

malignant carcinoid syndrome

,

,

hyperlipidemias

,

diabetes mellitus

,

metabolic syndrome

,

hyperlipoproteinemias

,

intraductal carcinoma noninfiltrating

,

,

echocardiography

,

environmental biomarkers

,

myocardial contraction

,

physiological sexual dysfunction

,

,

,

cognitive dysfunction

,

peripheral arterial disease

,

peripheral vascular diseases

,

radiation injuries

,

eye abnormalities

,

,

gastrointestinal microbiome

,

coronary artery disease

,

microvascular angina

,

,

aortic valve stenosis

,

serotonin syndrome

,

,

cardiac imaging techniques

,

,

early detection of cancer

,

breast cancer lymphedema

,

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